The Brief: Karen Took the Kids is a meme satirizing an imaginary, angry woman named Karen running away with her kids.

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Karen Took the Kids features the antagonist Karen who has run away, supposedly unfairly, with her kids. The meme usually takes the point of view of Karen’s scorned husband. The character Karen, though fictional, is typed as middle-aged, high-maintenance, and prone to angry outbursts or taking drastic measures. She is assumed to have an “I’d like to speak to your manager” haircut and was in that way born out of an existing meme.
Damnit Karen from dankmemes