The Brief: "Bofa" is the punchline to a simplistic dirty joke.

Bluesquiggle
DEEP DIVE

As they do with Ligma, pranksters will prompt someone to ask “what’s bofa?” so that they can respond “bofa deez nuts!” or “bofa deez nuts in your mouth!” The joke is that the phrase sounds like “both of these nuts,” a reference to testicles. Sometimes it is talked about as a fake disease that can lead to Ligma.

Other variations of this joke include “sugma” (suck my…), “E-TMA” (eat my …) and “Enya” (in your mouth).