The Brief: As a verb, to "thizz" means to take a pill or hit of Ecstacy.

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As an action, to thizz means to take a pill of ecstasy, or XTC. However, there are several other variations of the term.

Come on everybody now’s the chance
F**k the Harlem Shake, this the Thizzle Dance!

– Mac Dre, Thizzle Dance (2002)

“Thizz’n” refers to the act of being high on ecstasy, similar to tripping.  “Thizz Face” refers to someone’s facial expression while they’re high on ecstasy – it usually looks like the person smelled something bad.

Thizz originally derives from the “Thizzle Dance”, a song by San Francisco “Yay“-area rapper, Mac Dre.

The 2002 music video sparked the “Thizzle Dance Challenge”, similar to the Tik Tok Yee Haw Meme Challenge, where people would film themselves doing the Thizzle Dance and upload their videos on YouTube.