The Brief: PTFO is an acronym for "play the f**king objective" or "pass(ed) the f**k out."
Play The F**king Objective
This definition is used in reference to first-person shooter video games. It’s something that squad or team members may say to each other to remind them to focus on the overall objective in the game, rather than raising their individual kill count.
Pass The F**k Out
PTFO can be used to refer to someone falling asleep from exhaustion or passing out from excessive drinking.