The Brief: AMA means "ask me anything."

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The acronym originates from Reddit, where users can host AMA’s and respond to other users’ questions. Celebrity- or brand-hosted AMA’s will often go viral; this practice allows them to connect with fans more personally yet on a public platform.

Twitter users have also taken to hosting these tell-alls, though in a more tongue-in-cheek way. A user will tweet about an interesting experience or a controversial opinion and conclude with “AMA.” This invites other users to respond with questions, though the use of the phrase here is often more comedic than functional.

https://twitter.com/Mark_Neitzel23/status/1097676543092879360